Estudo de aterosclerose e fatores de risco em pacientes portadores de HTLV-1

Abstract

HTLV-1 infection induces a systemic inflammation and occasionally is associated with co infections. Atherosclerosis is closely related to the inflammatory process and its progression lasts for decades. Objectives: 1) To study the risk factors for cardiovascular diseases and atherosclerosis in patients infected by HTLV-1 . 2) To identify the thickening of the intimal-medial layer. 3) To evaluate the association between intimal thickening of the intima , the presence of HAM / TSP , ultrasensitive C-reactive protein and cardiovascular risk factors (age, sex, hypertension , hypercholesterolemia , diabetes mellitus and smoking).Study Design: Cross-sectional observational study. Methods: this study was carried out at the Center for HTLV / EBMSP, Salvador, Brazil, in the period between April, 2012 to September, 2013 The outcome of interest was the presence of atherosclerosis. Sociodemographic and cardiovascular risk factors were evaluated. Results 54 patients were enrolled, with a mean age (SD) of 57.06 (12.33) years, median (p25 - p75) to 57 (46.8 to 65.0) years and predominantly composed of women (72.2%), 41% of women and 3% of men had atherosclerosis. Conclusions: No association was observed between HTLV-1 and clinical or subclinical atherosclerosis as well as with the risk for cardiovascular diseases. A positive association between atherosclerosis and age was observed.