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dc.contributor.authorMendes, Ana Verena Almeida-
dc.contributor.authorLeal, Helena Ferreira-
dc.contributor.authorAzevedo, Jailton-
dc.contributor.authorSilva, Giulyana Evelyn Oliveira-
dc.contributor.authorAmorim, Angelica Maria Lima-
dc.contributor.authorRoma, Larissa Rangel Cabral de-
dc.contributor.authorArraes, Ana Carolina Palmeira-
dc.contributor.authorGouveia, Edilane Lins-
dc.contributor.authorReis, Mitermayer Galvão-
dc.contributor.authorSilva, Marcio de Oliveira-
dc.contributor.authorBarberino, Maria Goreth-
dc.contributor.authorMartins, Ianick Souto-
dc.contributor.authorReis, Joice Neves-
dc.date.accessioned2019-10-02T11:31:17Z-
dc.date.available2019-10-02T11:31:17Z-
dc.date.issued2019-07-11-
dc.identifier.issn1471-2334-
dc.identifier.urihttps://repositorio.bahiana.edu.br:8443/jspui/handle/bahiana/3378-
dc.description.abstractBACKGROUND: Bloodstream infections (BSI) are associated with high morbidity and mortality. This scenario worsens with the emergence of drug-resistant pathogens, resulting in infections which are difficult to treat or even untreatable with conventional antimicrobials. The aim of this study is to describe the epidemiological aspects of BSI caused by multiresistant gram-negative bacilli (MDR-GNB). METHODS: We conducted a laboratory-based surveillance for gram-negative bacteremia over a 1-year period. The bacterial isolates were identified by MALDI-TOF/MS and the antimicrobial susceptibility testing was performed by VITEK®2. Resistance genes were identified through PCR assays. RESULTS: Of the 143 patients, 28.7% had infections caused by MDR-GNB. The risk factors for MDR bacteremia were male sex, age ≥ 60, previous antimicrobial use, liver disease and bacteremia caused by K. pneumoniae. K. pneumoniae was the most frequently observed causative agent and had the highest resistance level. Regarding the resistance determinants, SHV, TEM, OXA-1-like and CTX-M-gp1 were predominant enzymatic variants, whereas CTX-M-gp9, CTX-M-gp2, KPC, VIM, GES, OXA-48-like, NDM and OXA-23-like were considered emerging enzymes. CONCLUSIONS: Here we demonstrate that clinically relevant antibiotic resistance genes are prevalent in this setting. We hope our findings support the development of intervention measures by policy makers and healthcare professionals to face antibiotic resistance.pt_BR
dc.language.isoenpt_BR
dc.sourcehttps://doi.org/10.1186/s12879-019-4265-zpt_BR
dc.subjectAntibiotic resistance; Bacteremia; Gram-negative bacteriapt_BR
dc.titleBloodstream infections caused by multidrug-resistant gram-negative bacteria: epidemiological, clinical and microbiological featurespt_BR
dc.title.alternativeBMC Infectious Diseasespt_BR
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