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https://repositorio.bahiana.edu.br:8443/jspui/handle/bahiana/3017
Título: | Serum antiphospholipid antibody levels as biomarkers for diagnosis of pulmonary tuberculosis patients |
Título(s) alternativo(s): | The International Journal of Tuberculosis and Lung Disease |
Autor(es): | Machado Júnior, Almério de Souza Takenami, Iukary Oliveira, Carolina C.de Petrilli, J. D Riley, Lee W. Arruda, Sérgio |
Palavras-chave: | Cardiolipin; Phosphatidylcholine; Phosphatidylethanolamine; Phosphatidylinositol; Sulfatide |
Data do documento: | 3-Abr-2018 |
Resumo: | OBJECTIVE: To evaluate the immunoglobulin (Ig)M and total IgG antibody response to cardiolipin (CL), phosphatidylcholine (PTC), hosphatidylethanolamine (PE), phosphatidylinositol (PI) and sulfatide (SL-I) as biosignatures that can be used to diagnose pulmonary tuberculosis (TB) and its applicability for monitoring the efficacy of anti-tuberculosis treatment. DESIGN: Serum samples from 37 adult pulmonary TB patients and 48 controls (16 healthy household contacts, 19 household contacts with latent tuberculous infection [LTBI] and 13 non-TB patients with lung disease) were screened using enzyme-linked immunosorbent assays (ELISAs) for IgM and total IgG against phospholipids. RESULTS: Levels of IgM response to CL, PE and PI, and IgG response to CL, PE, PI and PTC were significantly higher in TB patients than in control groups. Anti-CL IgG had the best performance characteristics, with a sensitivity and specificity of respectively 86.5% and 87.2%. This IgG anti-CL ELISA test detected 86.5% (32/37) of the TB patients, whereas the number detected using sputum smear was only 65.9% (24/37). After antituberculosis treatment, the median value for all ntiphospholipid antibodies decreased significantly compared with baseline values (P , 0.05). CONCLUSION: Our results suggest that the total IgG anti-CL level could be useful to complement conventional bacteriological tests for the rapid diagnosis of adult pulmonary TB. |
URI: | http://www7.bahiana.edu.br//jspui/handle/bahiana/3017 |
ISSN: | 1063–1070 |
Aparece nas coleções: | Artigos Completos Publicados em Periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO- ALMERIO DE SOUZA MACHADO JUNIOR - 2018.pdf | 644,46 kB | Adobe PDF | Visualizar/Abrir |
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