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dc.contributor.authorRibeiro, Juliana Caldas-
dc.date.accessioned2018-09-19T13:12:08Z-
dc.date.available2018-09-19T13:12:08Z-
dc.date.issued2016-12-07-
dc.identifier.urihttp://www7.bahiana.edu.br//jspui/handle/bahiana/2493-
dc.descriptionPatients with ischemic heart failure (iHF) have a high risk of neurological complications such as cognitive impairment and stroke. We hypothesized that iHF patients have a higher incidence of impaired dynamic cerebral autoregulation (dCA). Adult patients with iHF and healthy volunteers were included. Cerebral blood flow velocity (CBFV, transcranial Doppler, middle cerebral artery), end-tidal CO2 (capnography), and arterial blood pressure (Finometer) were continuously recorded supine for 5 min at rest. Autoregulation index (ARI) was estimated from the CBFV step response derived by transfer function analysis using standard template curves. Fifty-two iHF patients and 54 age-, gender-, and BP-matched healthy volunteers were studied. Echocardiogram ejection fraction was 40 (20–45) % in iHF group. iHF patients compared with control subjects had reduced end-tidal CO2 (34.1 3.7 vs. 38.3 4.0 mmHg, P 0.001) and lower ARI values (5.1 1.6 vs. 5.9 1.0, P 0.012). ARI 4, suggestive of impaired CA, was more common in iHF patients (28.8 vs. 7.4%, P 0.004). These results confirm that iHF patients are more likely to have impaired dCA compared with age-matched controls. The relationship between impaired dCA and neurological complications in iHF patients deserves further investigation.pt_BR
dc.description.localpubSalvador/BApt_BR
dc.language.isoenpt_BR
dc.subjectIntegration cardiovascular. Integration Renal. Cerebral blood flow autoregulation in ischemic heart failure.pt_BR
dc.titleResearch Article Cardiovascular and Renal Integration Cerebral blood flow autoregulation in ischemic heart failurept_BR
dc.title.alternativeAJP-Regul Integr Comp Physiol • doi:10.1152/ajpregu.00361.2016pt_BR
dc.typeProdução técnica: Outra produção técnicapt_BR
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